| First Author | Symonds H | Year | 1994 |
| Journal | Cell | Volume | 78 |
| Issue | 4 | Pages | 703-11 |
| PubMed ID | 8069917 | Mgi Jnum | J:55471 |
| Mgi Id | MGI:1340296 | Doi | 10.1016/0092-8674(94)90534-7 |
| Citation | Symonds H, et al. (1994) p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78(4):703-11 |
| abstractText | To determine the contribution of p53 loss to tumor progression, we have induced abnormal proliferation in the brain choroid plexus epithelium of transgenic mice using a SV40 T antigen fragment that perturbs pRB family function but does not affect p53 function. Tumors induced by this mutant develop slowly compared with those induced by wild-type T antigen. Suppressed tumor growth is directly attributable to p53 function, since rapid tumor development occurs when the T antigen fragment is expressed in p53-null mice. In p53-heterozygous mice, stochastic loss of the wild-type p53 allele results in the focal emergence of aggressive tumor nodules characteristic of tumor progression. In each case, aggressive tumor development in the absence of p53 function corresponds to a decrease in the level of apoptosis. These results provide in vivo evidence that p53-dependent apoptosis, occurring in response to oncogenic events, is a critical regulator of tumorigenesis. |
