| First Author | Döppler H | Year | 2016 |
| Journal | Sci Rep | Volume | 6 |
| Pages | 33758 | PubMed ID | 27649783 |
| Mgi Jnum | J:299314 | Mgi Id | MGI:6223166 |
| Doi | 10.1038/srep33758 | Citation | Doppler H, et al. (2016) The PRKD1 promoter is a target of the KRas-NF-kappaB pathway in pancreatic cancer. Sci Rep 6:33758 |
| abstractText | Increased expression of PRKD1 and its gene product protein kinase D1 (PKD1) are linked to oncogenic signaling in pancreatic ductal adenocarcinoma, but a direct functional relationship to oncogenic KRas has not been established so far. We here describe the PRKD1 gene promoter as a target for oncogenic KRas signaling. We demonstrate that KRas-induced activation of the canonical NF-kappaB pathway is one mechanism of how PRKD1 expression is increased and identify the binding sites for NF-kappaB in the PRKD1 promoter. Altogether, these results describe a novel mechanism governing PRKD1 gene expression in PDA and provide a functional link between oncogenic KRas, NF-kappaB and expression of PRKD1. |
