| First Author | Kilzheimer M | Year | 2015 |
| Journal | Eur J Immunol | Volume | 45 |
| Issue | 12 | Pages | 3441-53 |
| PubMed ID | 26361887 | Mgi Jnum | J:233734 |
| Mgi Id | MGI:5787906 | Doi | 10.1002/eji.201545475 |
| Citation | Kilzheimer M, et al. (2015) NF-kappaB-dependent signals control BOB.1/OBF.1 and Oct2 transcriptional activity in B cells. Eur J Immunol 45(12):3441-53 |
| abstractText | The transcriptional co-activator BOB.1/OBF.1 is crucial for Octamer-driven transcription in B cells. BOB.1/OBF.1-deficiency leads to tremendous defects in B-cell development and function. Therefore, in the past research focused on the identification of BOB.1/OBF.1 target genes. However, the regulation of BOB.1/OBF.1 expression itself is poorly understood. Here we show that in B cells NF-kappaB as well as to some extent NFAT proteins are involved in the activation of basal as well as inducible BOB.1/OBF.1 expression by direct binding to the BOB.1/OBF.1 promoter. Moreover, the analysis of different inducers of NF-kappaB, like several TLR ligands, TNF-alpha, BAFF, or LTalpha1beta2, revealed that both the canonical and noncanonical NF-kappaB pathways are involved in the induction of BOB.1/OBF.1 gene. The identification of so far unknown inducers that regulate BOB.1/OBF.1 expression in B cells provides novel insights in the potential function of BOB.1/OBF.1 during different aspects of B-cell development and function. |
