| First Author | Yoshioka H | Year | 1998 |
| Journal | Cell | Volume | 94 |
| Issue | 3 | Pages | 299-305 |
| PubMed ID | 9708732 | Mgi Jnum | J:49484 |
| Mgi Id | MGI:1277589 | Doi | 10.1016/s0092-8674(00)81473-7 |
| Citation | Yoshioka H, et al. (1998) Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell 94(3):299-305 |
| abstractText | Signaling molecules such as Activin, Sonic hedgehog, Nodal, Lefty, and Vg1 have been found to be involved in determination of left-right (L-R) asymmetry in the chick, mouse, or frog. However, a common signaling pathway has not yet been identified in vertebrates. We report that Pitx2, a bicoid-type homeobox gene expressed asymmetrically in the left lateral plate mesoderm, may be involved in determination of L-R asymmetry in both mouse and chick. Since Pitx2 appears to be downstream of lefty-1 in the mouse pathway, we examined whether mouse Lefty proteins could affect the expression of Pitx2 in the chick. Our results indicate that a common pathway from lefty-1 to Pitx2 likely exists for determination of L-R asymmetry in vertebrates. |
