| First Author | Ikeda K | Year | 1995 |
| Journal | Neurol Res | Volume | 17 |
| Issue | 6 | Pages | 445-8 |
| PubMed ID | 8622800 | Mgi Jnum | J:33893 |
| Mgi Id | MGI:81297 | Citation | Ikeda K, et al. (1995) Neuroprotective effect of basic fibroblast growth factor on wobbler mouse motor neuron disease. Neurol Res 17(6):445-8 |
| abstractText | Basic fibroblast growth factor (bFGF) possesses neuroprotective effects on a variety of neurons. Here we report that it delays progression of motor neuron disease (MND) in the wobbler mouse. After initial diagnosis of MND at post-natal age 3-4 weeks, wobbler mice receive either recombinant human bFGF (1 mg kg-1, n = 10) or vehicle (n = 10), daily for weeks by subcutaneous injection in a blind fashion. We performed symptomatic and neuropathological assessments in both groups. The treatment was fulfilled at 7-8 weeks of age. In comparison with vehicle, bFGF treatment potentiated grip strength (p < 0.008), attenuated forelimb contracture (p < 0.003), and increased weight of the biceps muscle (p < 0.008). bFGF-treated mice retarded denervation muscle atrophy (p < 0.001) and degeneration of spinal motoneurons (p < 0.001). Our study shows that bFGF treatment is beneficial in a murine MND model. We provide a rationale that bFGF may have therapeutic potential in peripheral motor neuropathy or MND. |
