| First Author | Vergani L | Year | 1997 |
| Journal | Neurosci Lett | Volume | 228 |
| Issue | 1 | Pages | 41-4 |
| PubMed ID | 9197283 | Mgi Jnum | J:57351 |
| Mgi Id | MGI:1344325 | Doi | 10.1016/s0304-3940(97)00375-3 |
| Citation | Vergani L, et al. (1997) Effects of low doses of glycosaminoglycans and insulin-like growth factor-I on motor neuron disease in wobbler mouse. Neurosci Lett 228(1):41-4 |
| abstractText | In this study we examined the effects of insulin-like growth factor-I (IGF-I) and of glycosaminoglycans (GAGs) on the progressive motor neuron disease in wobbler mice. After clinical diagnosis at age 3 weeks, mice received daily subcutaneous injections of IGF-I, or GAGs, or saline for 3 weeks. The histometric analysis revealed that biceps muscle fiber diameter was reduced in wobbler mice and that treatments with GAGs and IGF-I prevented such a drop. The number of atrophic small fibers was markedly reduced and that of the larger ones augmented. No effects on body growth and biceps muscle weight were observed. The combined AChE-silver staining revealed that both treatments promoted intramuscular axonal sprouting. The typical decline of grip strength in wobbler mice was also prevented. This study suggests that GAGs and IGF-I administrations can retard the onset of motor deficit, and reduce muscle atrophy in wobbler mice. |
