| First Author | Wallace ME | Year | 1976 |
| Journal | Mouse News Lett | Volume | 55 |
| Pages | 10 | Mgi Jnum | J:13692 |
| Mgi Id | MGI:61874 | Citation | Wallace ME, et al. (1976) Exencephaly. Mouse News Lett 55:10 |
| abstractText | Full text of MNL contribution: Research News: A. Exencephaly. The condition Knights provisionally called hydrancephaly (MNL 47, 24) appears histologically to be identical with the pseudoencephaly recorded by Bonnevie in 1936 (GM2, 141-3.) It seems to be caused primarily by abnormal curvatures of the neural tube in the cervical region and not by an intrinsic abnormality of the brain. Exencephaly best describes it, and the symbol xn is proposed: the previous symbol hn is withdrawn. The ratio normal: abnormal in segregating litters, at 16 days gestation and at birth (where a grid-bottom cage is used for parturition) remains at about 6:l. Earlier mortality of affected animals is being studied. A very significant excess of proven carriers in segregating litters - an excess over the 2/3 expected for a fully penetrating recessive - suggests that some carriers are impenetrant homozygotes. (Wallace, and J.R. Anderson, Dept. of Histology, Addenbrookes Hospital, Cambridge.). |
