| First Author | Garber AT | Year | 1985 |
| Journal | Science | Volume | 227 |
| Issue | 4682 | Pages | 74-7 |
| PubMed ID | 3964960 | Mgi Jnum | J:7668 |
| Mgi Id | MGI:56137 | Doi | 10.1126/science.3964960 |
| Citation | Garber AT, et al. (1985) Selective loss of a family of gene transcripts in a hereditary murine cataract. Science 227(4682):74-7 |
| abstractText | The eye lens of the Fraser mouse contains a dominantly inherited cataract with reduced amounts of seven distinct but homologous gamma crystallins encoded by a family of gamma-crystallin genes. The results of experiments with cultured lenses, cell-free RNA translation, and Northern blot hybridization indicated a specific loss of the family of gamma-crystallin messenger RNA's in the Fraser mouse lens. Southern blot hybridization of genomic DNA's from normal and Fraser mice showed no differences in gamma-crystallin coding sequences. |
