| First Author | Garber AT | Year | 1983 |
| Journal | Exp Eye Res | Volume | 36 |
| Issue | 2 | Pages | 165-9 |
| PubMed ID | 6825736 | Mgi Jnum | J:6987 |
| Mgi Id | MGI:55458 | Doi | 10.1016/0014-4835(83)90002-7 |
| Citation | Garber AT, et al. (1983) Abnormalities of crystallins in the lens of the CatFraser mouse. Exp Eye Res 36(2):165-9 |
| abstractText | We have analysed, by column chromatography and two-dimensional electrophoresis, the soluble proteins present in the lenses of normal mice and of mice heterozygous (Cat/+) and homozygous (Cat/Cat) for the CatFraser mutation which causes a dominantly inherited cataract. In Cat/+ and Cat/Cat lenses, the gamma-crystallins comprise a smaller fraction, and the alpha-crystallins a greater fraction, of the total crystallins present than found in normal lenses. These changes in composition involve all the subunits of each crystallin class and show a dosage effect, the change being greater in Cat/Cat than Cat/+ lenses. In both Cat/+ and Cat/Cat lenses, the beta H-crystallin aggregate is lost and subunits are present which are not detectable in normal lenses. |
