| First Author | Barrette B | Year | 2008 |
| Journal | J Neurosci | Volume | 28 |
| Issue | 38 | Pages | 9363-76 |
| PubMed ID | 18799670 | Mgi Jnum | J:142759 |
| Mgi Id | MGI:3822098 | Doi | 10.1523/JNEUROSCI.1447-08.2008 |
| Citation | Barrette B, et al. (2008) Requirement of myeloid cells for axon regeneration. J Neurosci 28(38):9363-76 |
| abstractText | The role of CD11b+ myeloid cells in axonal regeneration was assessed using axonal injury models and CD11b-TK(mt-30) mice expressing a mutated HSV-1 thymidine kinase (TK) gene regulated by the myeloid-specific CD11b promoter. Continuous delivery of ganciclovir at a sciatic nerve lesion site greatly decreased the number of granulocytes/inflammatory monocytes and macrophages in the distal stump of CD11b-TK(mt-30) mice. Axonal regeneration and locomotor function recovery were severely compromised in ganciclovir-treated CD11b-TK(mt-30) mice. This was caused by an unsuitable growth environment rather than an altered regeneration capacity of neurons. In absence of CD11b+ cells, the clearance of inhibitory myelin debris was prevented, neurotrophin synthesis was abolished, and blood vessel formation/maintenance was severely compromised in the sciatic nerve distal stump. Spinal cord-injured axons also failed to regenerate through peripheral nerve grafts in the absence of CD11b+ cells. Therefore, myeloid cells support axonal regeneration and functional recovery by creating a growth-permissive milieu for injured axons. |
