| First Author | van Essen D | Year | 2000 |
| Journal | Philos Trans R Soc Lond B Biol Sci | Volume | 355 |
| Issue | 1395 | Pages | 351-5 |
| PubMed ID | 10794053 | Mgi Jnum | J:106317 |
| Mgi Id | MGI:3618030 | Doi | 10.1098/rstb.2000.0572 |
| Citation | van Essen D, et al. (2000) Role of B cells in maintaining helper T-cell memory. Philos Trans R Soc Lond B Biol Sci 355(1395):351-5 |
| abstractText | The cellular interactions involved in maintaining CD4+ T-cell memory have hitherto not been identified. In this report, we have investigated the role played by B cells in this process. We show that that long-lasting helper T-cell memory depends on the presence of B cells, but that direct antigen presentation by B cells is not required. These findings provide new insights into the mechanisms which underlie helper T-cell memory. They also suggest that the efficacy of future vaccines will depend critically on the inclusion of B- as well as T-cell epitopes. |
