| First Author | Mizoue S | Year | 2006 |
| Journal | Curr Eye Res | Volume | 31 |
| Issue | 2 | Pages | 129-36 |
| PubMed ID | 16500763 | Mgi Jnum | J:119687 |
| Mgi Id | MGI:3703133 | Doi | 10.1080/02713680500507200 |
| Citation | Mizoue S, et al. (2006) Role of angiotensin II receptor subtypes in conjunctival wound healing. Curr Eye Res 31(2):129-36 |
| abstractText | PURPOSE: To investigate the role of angiotensin II (Ang II) receptor subtypes in subconjunctival injury. METHODS: A wound-healing model was developed by subconjunctival blunt dissection in male wild-type, AT1a receptor-deficient (AT1aKO) and AT2 receptor-deficient (AT2KO) mice. Collagen deposition and cell infiltration were evaluated histologically. Expression of collagen, matrix metalloproteinase (MMP), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were determined by real-time PCR. RESULTS: Subconjunctival injury increased the infiltration of inflammatory cells, collagen deposition in the subconjunctival space, and the expression of collagen type I and type III, TIMP-1 and MMP2. In AT1aKO mice, collagen deposition, cell infiltration, and expression of collagen and TIMP-1 were inhibited, but MMP2 expression was enhanced. In contrast, in AT2KO mice, the increase in collagen deposition, cell infiltration, and expression of collagen and TIMP-1 were further enhanced. CONCLUSIONS: These results indicate that AT1a and AT2 receptor stimulation may in addition to other mechanisms be antagonistically involved in the wound-healing process after subconjunctival injury. |
