| First Author | Wang SS | Year | 2009 |
| Journal | Circ Cardiovasc Genet | Volume | 2 |
| Issue | 6 | Pages | 573-82 |
| PubMed ID | 20031637 | Mgi Jnum | J:182797 |
| Mgi Id | MGI:5316590 | Doi | 10.1161/CIRCGENETICS.109.860270 |
| Citation | Wang SS, et al. (2009) Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice. Circ Cardiovasc Genet 2(6):573-82 |
| abstractText | BACKGROUND: Disruption of the elastic lamina, as an early indicator of aneurysm formation, and vascular calcification frequently occur together in atherosclerotic lesions of humans. METHODS AND RESULTS: We now report evidence of shared genetic basis for disruption of the elastic lamina (medial disruption) and medial calcification in an F(2) mouse intercross between C57BL/6J and C3H/HeJ on a hyperlipidemic apolipoprotein E (ApoE(-/-)) null BACKGROUND: gene, known to mediate myocardial calcification. Using transgenic complementation, we show that Abcc6 also contributes to aortic medial calcification. CONCLUSIONS: Our data indicate that calcification, though possibly contributory, does not always lead to medial disruption and that in addition to aneurysm formation, medial disruption may be the precursor to calcification. |
