| First Author | Genovese T | Year | 2005 |
| Journal | J Neuroimmunol | Volume | 166 |
| Issue | 1-2 | Pages | 55-64 |
| PubMed ID | 16019083 | Mgi Jnum | J:106400 |
| Mgi Id | MGI:3618445 | Doi | 10.1016/j.jneuroim.2005.05.009 |
| Citation | Genovese T, et al. (2005) Involvement of 5-lipoxygenase in spinal cord injury. J Neuroimmunol 166(1-2):55-64 |
| abstractText | A traumatic spinal cord injury (SCI) induces a sequelae of events which conduce biochemical and cellular alterations. Here we compare the degree of spinal cord injury caused by the application of vascular clips, in mice lacking the 5-lipoxygenase and in the corresponding wild-type mice. Biochemical, immunohistochemical and functional studies revealed respectively an increase of neutrophils infiltration, of IL-1beta, TNF-alpha immunoreactivity, apoptosis (measured by Annexin-V staining) and loss of hind legs movement in SCI operated 5-LO wild-type mice. In contrast, the degree of (1) neutrophil infiltration at different time points, (2) cytokine expression (TNF-alpha and IL-1beta), (3) histological damage, (4) apoptosis, was markedly reduced in the tissues obtained from SCI operated 5-LO deficient mice and (5) the motor recovery was ameliorated. |
