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Allele : Apoa1<tm1Unc> apolipoprotein A-I; targeted mutation 1, University of North Carolina

Primary Identifier	MGI:1857127	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Apoa1
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

A genomic fragment containing exon 2 was replaced by a neomycin resistance cassette. The protein was not detectable in plasma by Ouchterlony double-immunodiffusion tests in homozygous mice.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
ApoA-I-,
Apo A1<->,
ApoA-I-,
Apo A1<->,
A1-,
apoa1tm1unc,
Apo A-1 KO,
apoa1tm1unc,
Apo A-1 KO,
A1-

earliestPublication:
Williamson R, et al. (1992) Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A 89(15):7134-8

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

3 Carried By

0 Driven By

92 Publication categories

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