| First Author | Osuga J | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 236 |
| Issue | 2 | Pages | 375-8 |
| PubMed ID | 9240444 | Mgi Jnum | J:41982 |
| Mgi Id | MGI:894899 | Doi | 10.1006/bbrc.1997.6951 |
| Citation | Osuga J, et al. (1997) Effects of apo E deficiency on plasma lipid levels in mice lacking APOBEC-1. Biochem Biophys Res Commun 236(2):375-8 |
| abstractText | Apolipoprotein (apo) B100 mRNA undergoes site specific C to U editing, generating a stop-translation codon of apo B48 in the small intestine. This reaction is catalyzed in an editosome which contains APOBEC-1, a catalytic subunit. To clarify the functional significance of the apo B mRNA editing in lipoprotein metabolism, we have generated APOBEC-1 knockout mice and double knockout mice which are deficient in both APOBEC-1 and apo E. The apo B mRNA editing activity was markedly reduced and complete elimination of apo B48 from the plasma was observed in APOBEC-1(-/-) mice. Plasma triglyceride levels significantly increased in the double knockout mice (APOBEC-1(-/-);apo E(-/-)) as compared to apo E(-/-) mice. These results suggest that APOBEC-1(-/-) mice are a valuable model for experiments designed to understand a role of apo B mRNA editing. |
