| First Author | Suski M | Year | 2013 |
| Journal | Biochim Biophys Acta | Volume | 1834 |
| Issue | 12 | Pages | 2463-9 |
| PubMed ID | 23988828 | Mgi Jnum | J:204091 |
| Mgi Id | MGI:5529576 | Doi | 10.1016/j.bbapap.2013.08.008 |
| Citation | Suski M, et al. (2013) The influence of angiotensin-(1-7) Mas receptor agonist (AVE 0991) on mitochondrial proteome in kidneys of apoE knockout mice. Biochim Biophys Acta 1834(12):2463-9 |
| abstractText | Excessive action of angiotensin II on mitochondria has been shown to play an important role in mitochondrial dysfunction, a common feature of atherogenesis and kidney injury. Angiotensin-(1-7)/Mas receptor axis constitutes a countermeasure to the detrimental effects of angiotensin II on AT1 receptors. The aim of the study was to assess the effects of angiotensin-(1-7) peptidomimetic AVE0991 on the kidney mitochondrial proteome in widely used animal model of atherosclerosis (apoE(-/-) mice). Proteins changed in apoE(-/-) mice belonged to the groups of antioxidant enzymes, apoptosis regulators, inflammatory factors and metabolic enzymes. Importantly, AVE0991 partially reversed atherosclerosis-related changes in apoE(-/-) mice. |
