| First Author | Mukhamedova N | Year | 2011 |
| Journal | Biochem Biophys Res Commun | Volume | 412 |
| Issue | 3 | Pages | 446-9 |
| PubMed ID | 21839726 | Mgi Jnum | J:176065 |
| Mgi Id | MGI:5288274 | Doi | 10.1016/j.bbrc.2011.07.113 |
| Citation | Mukhamedova N, et al. (2011) Global functional knockdown of ATP binding cassette transporter A1 stimulates development of atherosclerosis in apoE K/O mice. Biochem Biophys Res Commun 412(3):446-9 |
| abstractText | ABCA1 is a key element of cellular cholesterol homeostasis. ApoE K/O mice fed with high-fat diet were infused with anti-ABCA1 antibody or control IgM. Infusion of anti-ABCA1 antibody led to 72% increase in the area of atherosclerotic plaque in aorta. After 16weeks on high-fat diet plasma level of high density lipoprotein cholesterol (HDL-C) was reduced in control group, but was unchanged in mice infused with anti-ABCA1 antibody. Total plasma cholesterol level was elevated while the capacity of plasma to support cholesterol efflux ex vivo was reduced after 16weeks on high-fat diet; the effects were similar in the two groups. We conclude that functional blocking of ABCA1-dependent cholesterol efflux stimulates development of atherosclerosis in apoE K/O mice independently from HDL-C levels. |
