| First Author | Nitta T | Year | 2015 |
| Journal | EMBO Rep | Volume | 16 |
| Issue | 5 | Pages | 638-53 |
| PubMed ID | 25770130 | Mgi Jnum | J:222872 |
| Mgi Id | MGI:5645846 | Doi | 10.15252/embr.201540096 |
| Citation | Nitta T, et al. (2015) The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gammadeltaT cells. EMBO Rep 16(5):638-53 |
| abstractText | The thymus provides a specialized microenvironment in which distinct subsets of thymic epithelial cells (TECs) support T-cell development. Here, we describe the significance of cortical TECs (cTECs) in T-cell development, using a newly established mouse model of cTEC deficiency. The deficiency of mature cTECs caused a massive loss of thymic cellularity and impaired the development of alphabetaT cells and invariant natural killer T cells. Unexpectedly, the differentiation of certain gammadeltaT-cell subpopulations-interleukin-17-producing Vgamma4 and Vgamma6 cells-was strongly dysregulated, resulting in the perturbation of gammadeltaT-mediated inflammatory responses in peripheral tissues. These findings show that cTECs contribute to the shaping of the TCR repertoire, not only of "conventional" alphabetaT cells but also of inflammatory "innate" gammadeltaT cells. |
