| First Author | Chaudhury C | Year | 2003 |
| Journal | J Exp Med | Volume | 197 |
| Issue | 3 | Pages | 315-22 |
| PubMed ID | 12566415 | Mgi Jnum | J:110885 |
| Mgi Id | MGI:3641489 | Doi | 10.1084/jem.20021829 |
| Citation | Chaudhury C, et al. (2003) The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197(3):315-22 |
| abstractText | The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a catabolic fate by a receptor-mediated mechanism much like that proposed for IgG. We show here that albumin binds FcRn in a pH dependent fashion, that the lifespan of albumin is shortened in FcRn-deficient mice, and that the plasma albumin concentration of FcRn-deficient mice is less than half that of wild-type mice. These results affirm the hypothesis that the major histocompatibility complex-related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both. |
