| First Author | de Goër de Herve MG | Year | 2010 |
| Journal | J Immunol | Volume | 185 |
| Issue | 2 | Pages | 1028-36 |
| PubMed ID | 20562265 | Mgi Jnum | J:162023 |
| Mgi Id | MGI:4462310 | Doi | 10.4049/jimmunol.0904209 |
| Citation | de Goer de Herve MG, et al. (2010) Direct CD4 help provision following interaction of memory CD4 and CD8 T cells with distinct antigen-presenting dendritic cells. J Immunol 185(2):1028-36 |
| abstractText | Accumulating evidence suggests that CD4 help is needed at the memory stage to mount effective secondary CD8 T cell responses. In this paper, we report that memory CD4 T cells can provide efficient help to memory CD8 T cells after interaction of the two lymphocytes with distinct dendritic cells. Provision of help to CD8 T cells required direct cell-cell contact and involved both IL-2 and CD40 ligation, within a CD4-CD8 T cell synapse. Thus, following antigenic interaction with APCs, activated memory CD4 and CD8 T cells appear to separate from their respective APCs before meeting each other for help provision, regardless of their Ag specificity. CD4 help for memory CD8 T cells therefore appears to be conditioned primarily not by Ag specificity but by activation status. |
