| First Author | Collins A | Year | 2024 |
| Journal | Cell | Volume | 187 |
| Issue | 6 | Pages | 1402-1421.e21 |
| PubMed ID | 38428422 | Mgi Jnum | J:346164 |
| Mgi Id | MGI:7613842 | Doi | 10.1016/j.cell.2024.02.002 |
| Citation | Collins A, et al. (2024) Maternal inflammation regulates fetal emergency myelopoiesis. Cell 187(6):1402-1421.e21 |
| abstractText | Neonates are highly susceptible to inflammation and infection. Here, we investigate how late fetal liver (FL) mouse hematopoietic stem and progenitor cells (HSPCs) respond to inflammation, testing the hypothesis that deficits in the engagement of emergency myelopoiesis (EM) pathways limit neutrophil output and contribute to perinatal neutropenia. We show that fetal HSPCs have limited production of myeloid cells at steady state and fail to activate a classical adult-like EM transcriptional program. Moreover, we find that fetal HSPCs can respond to EM-inducing inflammatory stimuli in vitro but are restricted by maternal anti-inflammatory factors, primarily interleukin-10 (IL-10), from activating EM pathways in utero. Accordingly, we demonstrate that the loss of maternal IL-10 restores EM activation in fetal HSPCs but at the cost of fetal demise. These results reveal the evolutionary trade-off inherent in maternal anti-inflammatory responses that maintain pregnancy but render the fetus unresponsive to EM activation signals and susceptible to infection. |
