| First Author | Berg RE | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 1 | Pages | 33-43 |
| PubMed ID | 10435577 | Mgi Jnum | J:110475 |
| Mgi Id | MGI:3640269 | Doi | 10.1016/s1074-7613(00)80079-5 |
| Citation | Berg RE, et al. (1999) Positive selection of an H2-M3 restricted T cell receptor. Immunity 11(1):33-43 |
| abstractText | Thymocytes are positively selected for alphabeta T cell antigen receptors (TCR) that recognize antigen in conjunction with self-major histocompatibility complex (MHC) molecules. MHC bound peptides participate in positive selection; however, their role has remained controversial. A TCR transgenic mouse was established using a TCR restricted to the MHC class Ib molecule, H2-M3. Having defined H2-M3 as the positively selecting MHC molecule, the severely limited number of H2-M3 binding peptides allowed us to characterize an NADH dehydrogenase subunit 1 (ND1)-derived peptide as the physiological ligand of positive selection. This peptide bears no apparent sequence homology to the cognate peptide, is expressed ubiquitously, and yet does not interfere with peripheral T cells. Our studies also suggest that positive selection becomes promiscuous at high epitope densities. |
