| First Author | Coles MC | Year | 1994 |
| Journal | J Exp Med | Volume | 180 |
| Issue | 1 | Pages | 395-9 |
| PubMed ID | 8006596 | Mgi Jnum | J:110734 |
| Mgi Id | MGI:3640991 | Doi | 10.1084/jem.180.1.395 |
| Citation | Coles MC, et al. (1994) Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes. J Exp Med 180(1):395-9 |
| abstractText | A small subset of functionally active CD4+ CD8- thymocytes express the NK1.1 marker, as do most CD4-CD8- NK1.1+ thymocytes. Previous studies have failed to implicate a role for major histocompatibility complex (MHC) or related molecules in the selection of the CD4+ CD8- NK1.1+ subset. We report here that the development of most of these cells is sharply reduced in class I-deficient mice, but not in class II-deficient mice. Hence, some CD4+ T cells are class I dependent and not class II dependent. Unlike conventional T cells, however, the development of NK1.1+ thymocytes in both the CD4+ CD8- and CD4- CD8- subsets is dependent on class I MHC expression by hematopoietic cells and not thymic epithelial cells. We propose that these populations are selected by nonpolymorphic class Ib or CD1 molecules. |
