| First Author | Buhlmann JE | Year | 1995 |
| Journal | Immunity | Volume | 2 |
| Issue | 6 | Pages | 645-53 |
| PubMed ID | 7540943 | Mgi Jnum | J:189416 |
| Mgi Id | MGI:5445493 | Doi | 10.1016/1074-7613(95)90009-8 |
| Citation | Buhlmann JE, et al. (1995) In the absence of a CD40 signal, B cells are tolerogenic. Immunity 2(6):645-53 |
| abstractText | When B cells are deprived of signaling through CD40, they exhibit the ability to induce T cell tolerance. The in vivo administration of anti-gp39 and allogeneic B cells diminished the ability of mice to mount an allogeneic response. Tolerance induction was specific for the haplotype expressed on the allogeneic B cells. Selective allospecific unresponsiveness was induced in the CD8 and CD4 compartments by the administration of anti-gp39 and class II-deficient B cells or class I-deficient B cells, respectively. As predicted by studies with anti-gp39 treatment, diminished allospecific responsiveness was induced by the administration of B cells to mice genetically deficient in gp39. Taken together, these data are consistent with the premise that deprivation of CD40 signaling engenders B cells with enhanced tolerogenicity. These studies provide insights into the tolerogenic capacity of resting B cells and outlines a practical approach to exploit this function. |
