| First Author | Murali-Krishna K | Year | 1999 |
| Journal | Science | Volume | 286 |
| Issue | 5443 | Pages | 1377-81 |
| PubMed ID | 10558996 | Mgi Jnum | J:58469 |
| Mgi Id | MGI:1347699 | Doi | 10.1126/science.286.5443.1377 |
| Citation | Murali-Krishna K, et al. (1999) Persistence of memory CD8 T cells in MHC class I-deficient mice [see comments]. Science 286(5443):1377-81 |
| abstractText | An understanding of how T cell memory is maintained is crucial for the rational design of vaccines. Memory T cells were shown to persist indefinitely in major histocompatibility complex (MHC) class I-deficient mice and retained the ability to make rapid cytokine responses upon reencounter with antigen. In addition, memory CD8 T cells, unlike naive cells, divided without MHC-T cell receptor interactions. This 'homeostatic' proliferation is likely to be important in maintaining memory T cell numbers in the periphery. Thus, after naive CD8 T cells differentiate into memory cells, they evolve an MHC class I-independent 'life-style' and do not require further stimulation with specific or cross-reactive antigen for their maintenance. |
