| First Author | Causing CG | Year | 1997 |
| Journal | Neuron | Volume | 18 |
| Issue | 2 | Pages | 257-67 |
| PubMed ID | 9052796 | Mgi Jnum | J:127889 |
| Mgi Id | MGI:3765185 | Doi | 10.1016/s0896-6273(00)80266-4 |
| Citation | Causing CG, et al. (1997) Synaptic innervation density is regulated by neuron-derived BDNF. Neuron 18(2):257-67 |
| abstractText | In this report, we have examined the role of neuron-derived BDNF at an accessible synapse, that of preganglionic neurons onto their sympathetic neuron targets. Developing and mature sympathetic neurons synthesize BDNF, and preganglionic neurons express the full-length BDNF/TrkB receptor. When sympathetic neuron-derived BDNF is increased 2- to 4-fold in transgenic mice, preganglionic cell bodies and axons hypertrophy, and the synaptic innervation to sympathetic neurons is increased. Conversely, when BDNF synthesis is eliminated in BDNF -/- mice, preganglionic synaptic innervation to sympathetic neurons is decreased. Together these results indicate that variations in neuronal neurotrophin synthesis directly regulate neuronal circuitry by selectively modulating synaptic innervation density. |
