| First Author | Alberto JM | Year | 2007 |
| Journal | Mol Genet Metab | Volume | 91 |
| Issue | 4 | Pages | 396-8 |
| PubMed ID | 17562377 | Mgi Jnum | J:123017 |
| Mgi Id | MGI:3716247 | Doi | 10.1016/j.ymgme.2007.05.002 |
| Citation | Alberto JM, et al. (2007) Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway. Mol Genet Metab 91(4):396-8 |
| abstractText | Cystathionine beta synthase (CBS) deficiency is a metabolic disorder that is biochemically characterized by severe hyperhomocysteinemia. In order to show the effects of CBS deficiency onto the activity of the enzymes involved in the remethylation pathway, we used the well characterized genetic model of severe hyperhomocysteinemia in mice. We showed that CBS deficiency in mice reduced hepatic methionine synthase and betaine-homocysteine methyltransferase activities, whereas 5,10-methylene tetrahydrofolate reductase activity was increased. |
