| First Author | Mackey MF | Year | 1998 |
| Journal | J Immunol | Volume | 161 |
| Issue | 5 | Pages | 2094-8 |
| PubMed ID | 9725199 | Mgi Jnum | J:118387 |
| Mgi Id | MGI:3699524 | Doi | 10.4049/jimmunol.161.5.2094 |
| Citation | Mackey MF, et al. (1998) Dendritic cells require maturation via CD40 to generate protective antitumor immunity. J Immunol 161(5):2094-8 |
| abstractText | A critical role for CD40/CD154 interactions in the generation of protective cell-mediated tumor immunity has been demonstrated previously. Herein, we show that the failure to generate systemic tumor immunity in the absence of CD40/CD154 interactions correlates with an inhibition of Th1-type cytokine production following tumor vaccination. Furthermore, protective antitumor responses can be restored in CD40-deficient mice by the coadministration of CD40+/+ but not CD40-/- dendritic cells (DCs) with tumor Ag, suggesting that CD40 is critical for the maturation and function of DCs in vivo. Finally, we demonstrate that an IL-12-transduced but not a mock-transduced tumor vaccine induces systemic tumor immunity in anti-CD154-treated and CD154-deficient mice. These data suggest that impaired antitumor responses in the absence of CD40/CD154 interactions are the result of a lesion in APC function, namely IL-12 production, and that CD40 plays a critical role in the maturation of DCs in vivo. |
