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Publication : Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis.

First Author  Roussel-Gervais A Year  2010
Journal  Mol Endocrinol Volume  24
Issue  9 Pages  1835-45
PubMed ID  20660298 Mgi Jnum  J:182846
Mgi Id  MGI:5316957 Doi  10.1210/me.2010-0091
Citation  Roussel-Gervais A, et al. (2010) Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis. Mol Endocrinol 24(9):1835-45
abstractText  Cushing's disease is caused by glucocorticoid-resistant pituitary corticotroph adenomas. We have previously identified the loss of nuclear Brg1 as one mechanism that may lead to partial glucocorticoid resistance: this loss is observed in about 33% of human corticotroph adenomas. We now show that Brg1 loss of function correlates with cyclin E expression in corticotroph adenomas and with loss of the cell cycle inhibitor p27(Kip1) expression. Because Brg1 is thought to have tumor suppressor activity, the present study was undertaken to understand the putative contribution of cyclin E derepression produced by loss of Brg1 expression on adenoma development. Overexpression of cyclin E in pituitary proopiomelanocortin cells leads to abnormal reentry into cell cycle of differentiated proopiomelanocortin cells and to centrosome instability. These alterations are consistent with the intermediate lobe hyperplasia and anterior lobe adenomas that were observed in these pituitaries. When combined with the p27(Kip1) knockout, overexpression of cyclin E increased the incidence of pituitary tumors, their size, and their proliferation index. These results suggest that cyclin E up-regulation and p27(Kip1) loss-of-function act cooperatively on pituitary adenoma development.
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