| First Author | Jones A | Year | 2016 |
| Journal | Immunity | Volume | 45 |
| Issue | 5 | Pages | 1066-1077 |
| PubMed ID | 27793593 | Mgi Jnum | J:264695 |
| Mgi Id | MGI:6141484 | Doi | 10.1016/j.immuni.2016.10.008 |
| Citation | Jones A, et al. (2016) Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells. Immunity 45(5):1066-1077 |
| abstractText | Dendritic cells (DCs) initiate immunity and also antigen-specific tolerance mediated by extrathymic regulatory T (Treg) cells, yet it remains unclear how DCs regulate induction of such tolerance. Here, we report that efficient induction of Treg cells was instructed by BTLA(+)DEC205(+)CD8(+)CD11c(+) DCs and the immunomodulatory functions of BTLA. In contrast, T cell activation in steady state by total CD11c(+) DCs that include a majority of DCs that do not express BTLA did not induce Treg cells and had no lasting impact on subsequent immune responses. Engagement of HVEM, a receptor of BTLA, promoted Foxp3 expression in T cells through upregulation of CD5. In contrast, T cells activated in the absence of BTLA and HVEM-mediated functions remained CD5(lo) and therefore failed to resist the inhibition of Foxp3 expression in response to effector cell-differentiating cytokines. Thus, DCs require BTLA and CD5-dependent mechanisms to actively adjust tolerizing T cell responses under steady-state conditions. |
