| First Author | Olsson T | Year | 1993 |
| Journal | Cell | Volume | 72 |
| Issue | 5 | Pages | 715-27 |
| PubMed ID | 8453666 | Mgi Jnum | J:112991 |
| Mgi Id | MGI:3664169 | Doi | 10.1016/0092-8674(93)90400-k |
| Citation | Olsson T, et al. (1993) CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule. Cell 72(5):715-27 |
| abstractText | T. brucei brucei released a lymphocyte triggering factor (TLTF), which triggered purified CD8+, but not CD4+, T cells to interferon gamma (IFN-gamma) mRNA expression and secretion and to [3H]thymidine incorporation. TLTF also induced mRNA for transforming growth factor beta, but not for interleukin-4. The action of this TLTF on mononuclear cell (MNC) cultures was blocked by anti-CD8 antibodies and by soluble CD8. MNCs from a mutant mouse strain lacking CD8 expression were not triggered by TLTF. IFN-gamma provides a growth stimulus for T. brucei brucei, and infected CD8- mice had much lower parasitemia and survived longer than CD8+ mice. The host-parasite interaction in experimental African trypanosomiasis thus involves parasite release of TLTF, which by binding to CD8 triggers CD8+ cells to produce the parasite growth-promoting cytokine IFN-gamma. |
