| First Author | Koh DR | Year | 1992 |
| Journal | Science | Volume | 256 |
| Issue | 5060 | Pages | 1210-3 |
| PubMed ID | 1589800 | Mgi Jnum | J:1033 |
| Mgi Id | MGI:49565 | Doi | 10.1126/science.256.5060.1210 |
| Citation | Koh DR, et al. (1992) Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science 256(5060):1210-3 |
| abstractText | Mice lacking in CD8 were generated from homologous recombination in embryonal stem cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)-susceptible PL/JH-2u through four backcross generations to investigate the role of CD8+ T cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This suggests that CD8+ T lymphocytes may participate as both effectors and regulators in this animal model. |
