| First Author | Tanchot C | Year | 1997 |
| Journal | Science | Volume | 276 |
| Issue | 5321 | Pages | 2057-62 |
| PubMed ID | 9197272 | Mgi Jnum | J:82165 |
| Mgi Id | MGI:2651386 | Doi | 10.1126/science.276.5321.2057 |
| Citation | Tanchot C, et al. (1997) Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276(5321):2057-62 |
| abstractText | The requisite molecular interactions for CD8 T cell memory were determined by comparison of monoclonal naive and memory CD8(+) T cells bearing the T cell receptor (TCR) for the HY antigen. Naive T cells required only the right major histocompatibility complex (MHC) class I-restricting molecule to survive; to expand, they also needed antigen. In contrast, for survival, memory cells did not require the restricting MHC allele, but needed only a nonspecific class I; for expansion the correct class I, but not antigen, was required. Thus, maintenance of CD8 T cell memory still required TCR-MHC class I interactions, but memory T cells may have a lower functional activation threshold that facilitates secondary responses. |
