| First Author | Recher M | Year | 2004 |
| Journal | Nat Immunol | Volume | 5 |
| Issue | 9 | Pages | 934-42 |
| PubMed ID | 15300247 | Mgi Jnum | J:92168 |
| Mgi Id | MGI:3051909 | Doi | 10.1038/ni1102 |
| Citation | Recher M, et al. (2004) Deliberate removal of T cell help improves virus-neutralizing antibody production. Nat Immunol 5(9):934-42 |
| abstractText | The B cell response to lymphocytic choriomeningitis virus is characterized by a CD4(+) T cell-dependent polyclonal hypergammaglobulinemia and delayed formation of virus-specific neutralizing antibodies. Here we provide evidence that, paradoxically, because of polyclonal B cell activation, virus-specific T cell help impairs the induction of neutralizing antibody responses. Experimental reduction in CD4(+) T cell help in vivo resulted in potent neutralizing antibody responses without impairment of CD8(+) T cell activity. These unexpected consequences of polyclonal B cell activation may affect vaccine strategies and the treatment of clinically relevant chronic bacterial, parasitic and viral infections in which hypergammaglobulinemia is regularly found. |
