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Allele : Cd28<tm1Mak> CD28 antigen; targeted mutation 1, Tak Mak

Primary Identifier	MGI:1857150	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Cd28
Transmission	Germline	Strain of Origin	129S2/SvPas
Is Recombinase	false	Is Wild Type	false

molecularNote

A genomic fragment containing part of exon 2 was replaced by a neomycin resistance cassette. Flow-cytometry analysis on peripheral blood lymphocytes demonstrated that the protein was not expressed in these cells in homozygous mice.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
CD28<->,
CD28<->,
CD28KO,
CD28KO

earliestPublication:
Shahinian A, et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261(5121):609-12

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

13 Carried By

0 Driven By

320 Publication categories

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