| First Author | Buhlmann JE | Year | 2003 |
| Journal | J Immunol | Volume | 170 |
| Issue | 11 | Pages | 5421-8 |
| PubMed ID | 12759417 | Mgi Jnum | J:83454 |
| Mgi Id | MGI:2662047 | Doi | 10.4049/jimmunol.170.11.5421 |
| Citation | Buhlmann JE, et al. (2003) A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection. J Immunol 170(11):5421-8 |
| abstractText | Although costimulation plays an important role in activating naive T cells, its role in negative selection is controversial. By following thymocyte deletion induced by endogenous superantigens in mice lacking B7-1 and/or B7-2, we have identified a role for both B7-1 and B7-2 in negative selection. Studies using CD28-deficient and CD28/CTLA-4-double-deficient mice have revealed that either CD28 or another as yet undefined coreceptor can mediate these B7-dependent signals that promote negative selection. Finally, CTLA-4 delivers signals that inhibit selection, suggesting that CTLA-4 and CD28 have opposing functions in thymic development. Combined, the data demonstrate that B7-1/B7-2-dependent signals help shape the T cell repertoire. |
