| First Author | Berg-Brown NN | Year | 2004 |
| Journal | J Exp Med | Volume | 199 |
| Issue | 6 | Pages | 743-52 |
| PubMed ID | 15024044 | Mgi Jnum | J:123989 |
| Mgi Id | MGI:3720303 | Doi | 10.1084/jem.20031022 |
| Citation | Berg-Brown NN, et al. (2004) PKCtheta signals activation versus tolerance in vivo. J Exp Med 199(6):743-52 |
| abstractText | Understanding the pathways that signal T cell tolerance versus activation is key to regulating immunity. Previous studies have linked CD28 and protein kinase C-theta (PKCtheta) as a potential signaling pathway that influences T cell activation. Therefore, we have compared the responses of T cells deficient for CD28 and PKCtheta in vivo and in vitro. Here, we demonstrate that the absence of PKCtheta leads to the induction of T cell anergy, with a phenotype that is comparable to the absence of CD28. Further experiments examined whether PKCtheta triggered other CD28-dependent responses. Our data show that CD4 T cell-B cell cooperation is dependent on CD28 but not PKCtheta, whereas CD28 costimulatory signals that augment proliferation can be uncoupled from signals that regulate anergy. Therefore, PKCtheta relays a defined subset of CD28 signals during T cell activation and is critical for the induction of activation versus tolerance in vivo. |
