| First Author | Cannon CM | Year | 2005 |
| Journal | Eur J Neurosci | Volume | 21 |
| Issue | 9 | Pages | 2600-4 |
| PubMed ID | 15932618 | Mgi Jnum | J:101069 |
| Mgi Id | MGI:3590453 | Doi | 10.1111/j.1460-9568.2005.04077.x |
| Citation | Cannon CM, et al. (2005) Mice lacking dopamine D1 receptors express normal lithium chloride-induced conditioned taste aversion for salt but not sucrose. Eur J Neurosci 21(9):2600-4 |
| abstractText | Conditioned taste aversion (CTA), is a form of Pavlovian learning wherein a novel flavour is powerfully associated with subsequent feelings of illness, and is afterwards avoided. In rats, pharmacological blockade of dopamine D1 receptors has been reported to prevent the expression of a CTA to the sweet taste of sucrose or saccharine. We used genetically modified mice to determine whether dopamine D1 receptors are necessary for the expression of a CTA. Food-deprived mice lacking the dopamine D1 receptor (D1r-/-) did not express a LiCl-induced (125 or 254 mg/kg) CTA to the sweet taste of 0.5 m sucrose, in agreement with previous pharmacological studies. However, water-deprived D1r-/- mice did express normal LiCl-induced (40, 150 and 254 mg/kg) CTA to a salty taste (0.2 m NaCl). Our results suggest that activation of D1 receptors might contribute to the strength of an aversive gustatory association, but might not be required for the formation of a CTA in general. |
