| First Author | Li F | Year | 2014 |
| Journal | J Immunol | Volume | 192 |
| Issue | 7 | Pages | 3021-8 |
| PubMed ID | 24563255 | Mgi Jnum | J:209892 |
| Mgi Id | MGI:5568880 | Doi | 10.4049/jimmunol.1302934 |
| Citation | Li F, et al. (2014) Inhibitory Fcgamma receptor is required for the maintenance of tolerance through distinct mechanisms. J Immunol 192(7):3021-8 |
| abstractText | The inhibitory FcgammaR FcgammaRIIB is widely expressed on B cells, dendritic cells (DCs), and myeloid effector cells and modulates a variety of Ab-driven in vivo functions. Although it has been established that FcgammaRIIB plays an important role in the maintenance of peripheral tolerance, the responsible cell-specific FcgammaRIIB expression remains to be determined. In this study, we generated mice with selective deletion of FcgammaRIIB in B cells, DCs, and myeloid effector cells and evaluated these novel strains in models of tolerance and autoimmune diseases. Our results demonstrate that mice with selective deletion of FcgammaRIIB expression in B cells and DCs have increased Ab and T cell responses, respectively, and display enhanced susceptibility to disease in distinct models, suggesting that FcgammaRIIB expression in distinct cellular populations contributes to the maintenance of peripheral tolerance through different mechanisms. |
