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Allele : Fcgr2b<tm1Ttk> Fc receptor, IgG, low affinity IIb; targeted mutation 1, Toshiyuki Takai
Primary Identifier  MGI:1857166 Allele Type  Targeted
Attribute String  Null/knockout Gene  Fcgr2b
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
molecularNote  A 2.3 kb genomic fragment containing the S1 and EC1 exons was replaced by a neomycin resistance cassette. Encoded transcript was undetectable in homozygous mutant mice via Northern blot analysis (data not shown). Western blot analysis of LPS-stimulated B cells derived from homozygous mice confirmed that no protein was made from this allele, and FACS analysis demonstrated that no functional protein was expressed on the cell surface of B cells in homozygous mice.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • FcgammaRIIB<->,
  • IIB-,
  • FcgammaRII,
  • FcgRIIB129<->,
  • TAC264,
  • Fcgr2b<tm1Rav>,
  • FcRIIB<->,
  • TAC264,
  • FcgRIIB129<->,
  • FcgammaRII,
  • FcgammaRIIb<->,
  • FcgammaRII2B-,
  • FcRIIB<->,
  • FcgammaRII-,
  • FcgammaRII2B-,
  • FcgammaRIIb<->,
  • IIB-,
  • FcgammaRII-,
  • Fcgr2b<tm1Rav>,
  • FcgammaRIIB<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

14 Carried By

0 Driven By

269 Publication categories





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