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Allele : Kdr<tm1Jrt> kinase insert domain protein receptor; targeted mutation 1, Janet Rossant

Primary Identifier  MGI:1857168 Allele Type  Targeted
Attribute String  Null/knockout, Reporter Gene  Kdr
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  Insertion of an in-frame lacZ gene and a loxP site flanked neomycin resistance gene cassette replaced the translated portion of the first coding exon and the proximal part of the next intron, and placed lacZ under the transcriptional control of the endogenous promoter. Neither RT-PCR using total RNA nor Western blot analysis using a carboxy terminal antibody detected gene expression in E8.5 homozygous mutant embryos.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • flk-1/lacZ,
  • flk-1-,
  • Flk1-lacZ neo-in,
  • Flk1lacZ,
  • Flk1-lacZ neo-in,
  • Flk1<lacZ>,
  • flk-1-,
  • Flk1-,
  • VEGFR-2<->,
  • Vegfr2<lacZ>,
  • Flk1<lacZ>,
  • Flk1-,
  • flk.lacZ,
  • Vegfr2<lacZ>,
  • flk.lacZ,
  • flk-1/lacZ,
  • Flk1lacZ,
  • VEGFR-2<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

82 Publication categories