| First Author | Thullier F | Year | 1997 |
| Journal | Brain Res Dev Brain Res | Volume | 100 |
| Issue | 1 | Pages | 22-8 |
| PubMed ID | 9174242 | Mgi Jnum | J:40361 |
| Mgi Id | MGI:87701 | Doi | 10.1016/s0165-3806(97)00010-2 |
| Citation | Thullier F, et al. (1997) Neurobehavioral evaluation of lurcher mutant mice during ontogeny. Brain Res Dev Brain Res 100(1):22-8 |
| abstractText | Lurcher mutant mice were compared to normal littermate controls for body weight, body righting, negative geotropism, sensorimotor coordination (rotating grid, wire suspension, rotorod), and visuomotor coordination requiring swimming toward a pole during postnatal (P) days 0-30. Lurcher mutants had a lower body weight on P20-P30 and were slower before performing the complete body righting response on P13-P30. Because of postural instability during the negative geotropism test, lurcher mutants turned quicker up the slope than normal mice. The mutants fell sooner from the rotating grid on P11-P14, from the horizontal wire on P15-P16, and from the rotorod on P14-P30. Lurcher mutants were also slower before swimming to the pole or climbing to the top of the pole and were inferior in pole climbing height on P22-P30. These results indicate test-selective and time-selective neurobehavioral deficits during ontogeny in a spontaneous cerebellar mutant. |
