| First Author | Lalonde R | Year | 2003 |
| Journal | Physiol Behav | Volume | 80 |
| Issue | 2-3 | Pages | 333-9 |
| PubMed ID | 14637233 | Mgi Jnum | J:96320 |
| Mgi Id | MGI:3530168 | Doi | 10.1016/j.physbeh.2003.08.006 |
| Citation | Lalonde R, et al. (2003) Motor coordination in mice with hotfoot, Lurcher, and double mutations of the Grid2 gene encoding the delta-2 excitatory amino acid receptor. Physiol Behav 80(2-3):333-9 |
| abstractText | Grid2(ho/ho) is a loss of function gene mutation resulting in abnormal dendritic arborizations of Purkinje cells. These mutants were compared in a series of motor coordination tests requiring balance and equilibrium to nonataxic controls (Grid2(ho/+)) and to a double mutant (Grid2(ho/Lc)) with an inserted Lc mutation. The performance of Grid2(ho/ho) mutant mice was poorer than that of controls on stationary beam, coat hanger, unsteady platform, and rotorod tests. Grid2(ho/Lc) did not differ from Grid2(Lc/+) mice. However, the insertion of the Lc mutation in Grid2(ho/Lc) potentiated the deficits found in Grid2(ho/ho) in stationary beam, unsteady platform, and rotorod tests. These results indicate a deleterious effect of the Lc mutation on Grid2-deficient mice. |
