| First Author | Belzung C | Year | 2001 |
| Journal | Behav Genet | Volume | 31 |
| Issue | 2 | Pages | 151-5 |
| PubMed ID | 11545532 | Mgi Jnum | J:71079 |
| Mgi Id | MGI:2149159 | Doi | 10.1023/a:1010269126295 |
| Citation | Belzung C, et al. (2001) The effects of the lurcher mutation on object localization, T-maze discrimination, and radial arm maze tasks. Behav Genet 31(2):151-5 |
| abstractText | The Lurcher mutation is characterized by degeneration of the cerebellar cortex and cerebellar ataxia. The mutants were compared to littermate controls of the same background strain in three spatial tasks: 1) left-right discrimination in a water-filled T-maze, a reference memory task requiring a win-stay strategy; 2) the radial arm maze, a working memory task requiring a win-shift strategy; 3) object localization, a reference memory task requiring the use of cognitive mapping. Lurcher mutants were impaired in the object localization and radial arm maze tasks but not in the left-right discrimination task. These results indicate that trial-independent tasks and reference memory tasks using cognitive mapping may be particularly vulnerable to cerebellar degeneration. |
