| First Author | Caddy KW | Year | 1997 |
| Journal | Eur J Pharmacol | Volume | 330 |
| Issue | 2-3 | Pages | 139-42 |
| PubMed ID | 9253946 | Mgi Jnum | J:43327 |
| Mgi Id | MGI:1097507 | Doi | 10.1016/s0014-2999(97)01030-3 |
| Citation | Caddy KW, et al. (1997) The effect of 3-acetylpyridine on inferior olivary neuron degeneration in Lurcher mutant and wild-type mice. Eur J Pharmacol 330(2-3):139-42 |
| abstractText | Lurcher mutant and wild-type mice were given intraperitoneal injections of 3-acetylpyridine to look at the toxic effects of this drug on the inferior olivary neurons. Intraperitoneal administration of 3-acetylpyridine is characterized by the different sensitivity of inferior olivary neurons in Lurcher mutant and wild-type mice. Lurcher mutants suffered a destruction of these neurons while wild-type mice were unaffected. The results show that there is a different effect of 3-acetylpyridine between genetic mutations and wild-type mice on the same inbred strain of mice. The different affinity of 3-acetylpyridine for the inferior olivary neurons of this mutant is briefly discussed. |
