| First Author | McNutt W | Year | 1967 |
| Journal | Anat Rec | Volume | 157 |
| Pages | 286 (Abstr.) | Mgi Jnum | J:12168 |
| Mgi Id | MGI:60418 | Citation | McNutt W (1967) Porcine tail, a new mutation in the house mouse. Anat Rec 157:286 (Abstr.) |
| abstractText | Full text of Abstract: 286. AMERICAN ASSOCIATION OF ANATOMISTS. McNutt, Wallace, Department of Anatomy, The Universitv of Texas Medical Branch, Galveston, Texas. Porcine tail, a new mutation in the house mouse. Porcine tail (pt) arose as a spontaneous autosomal recessive mutation in a strain of mice being maintained for the quivering (qv) gene. It has variable expression, depending upon the genetic background, and incomplete penetrance. It has been outcrossed to two strains of mice, IHB, a subline of BALB maintained for special characteristics, and a strain carrying tufted (tf). The gene was recovered from both crosses. Forty-four mating pairs of F1 mice were selected from the latter cross to test linkage with similar tail mutants located on chromosome IX (or linkage group IX) with tufted. F2 mice indicate that the genes tf and pt assort independently. The F1 mice are approaching the end of their reproductive lives and their offspring show that litter number, season of the year and age of parents have no obvious effects on the expression or penetrance of the gene, although this has not yet been analyzed for significance. There are fewer short-tailed mice than expected in the F2 generation. Sublines show differences in expression, as, for instance, one subline in which waltzing occurs and another subline in which none has chorea. The gene produces its effect on the tail by the 9th or 10th day of gestation when abnormalities in the neural plate can be seen. The variable expression and incomplete penetrance pose problems as yet unanswered and they offer an opportunity to study the developmental events that transpire in the interval between fertilization and the completely developed individual. (Supported by NIH Grant 5R01 NB 01147.) |
