| First Author | Huerta PT | Year | 1996 |
| Journal | Neuroreport | Volume | 7 |
| Issue | 10 | Pages | 1685-9 |
| PubMed ID | 8904782 | Mgi Jnum | J:36651 |
| Mgi Id | MGI:84078 | Doi | 10.1097/00001756-199607080-00032 |
| Citation | Huerta PT, et al. (1996) Preservation of spatial learning in fyn tyrosine kinase knockout mice. Neuroreport 7(10):1685-9 |
| abstractText | Previous work has shown that knockout mice lacking the fyn tyrosine kinase gene (fyn-/-) are impaired in spatial learning. Here, we have re-examined the spatial learning of fyn-/- mutants in an open field water maze. Unlike wild-type mice, fyn-/- knockouts often floated without moving when placed in the water but could swim adequately when their hind feet were mechanically stimulated. Under these conditions, fyn-/- mice showed significant improvement over trials in locating a hidden platform. On a transfer trial, at the end of training, they spent a disproportionate amount of time swimming in the location of the previously hidden platform. These findings suggest that fyn-/- knockouts are capable of spatial learning, but suffer an impairment that compromises their ability to swim normally. |
