| First Author | Seddon B | Year | 2002 |
| Journal | J Immunol | Volume | 169 |
| Issue | 6 | Pages | 2997-3005 |
| PubMed ID | 12218114 | Mgi Jnum | J:133734 |
| Mgi Id | MGI:3784089 | Doi | 10.4049/jimmunol.169.6.2997 |
| Citation | Seddon B, et al. (2002) TCR signals mediated by Src family kinases are essential for the survival of naive T cells. J Immunol 169(6):2997-3005 |
| abstractText | The role of TCR signals triggered by recognition of self MHCs in maintaining the survival of naive peripheral T cells remains controversial. Here we examine the role of the Src family kinases, p56(lck) (Lck) and p59(fyn) (Fyn), in the survival of naive T cells. We show that long term survival requires a combination of signals transduced by Src family kinases and signals through the IL-7R. In the absence of either one, naive T cells die slowly, but if both signals are removed, cell loss is greatly accelerated. The TCR signal can be mediated by either Fyn or Lck at wild-type levels of expression, but not by Lck alone if expressed suboptimally. The disappearance of T cells in the absence of Fyn and Lck was associated with a complete loss of TCRzeta-chain phosphorylation and down-regulation of CD5, both of which are also MHC contact dependent, indicating that the Src family kinases are critical for transducing a TCR-MHC survival signal. |
