| First Author | Krasowski MD | Year | 1998 |
| Journal | Neurosci Lett | Volume | 240 |
| Issue | 2 | Pages | 81-4 |
| PubMed ID | 9486477 | Mgi Jnum | J:107951 |
| Mgi Id | MGI:3622586 | Doi | 10.1016/s0304-3940(97)00929-4 |
| Citation | Krasowski MD, et al. (1998) A deficit of functional GABA(A) receptors in neurons of beta 3 subunit knockout mice. Neurosci Lett 240(2):81-4 |
| abstractText | Mice whose gamma-aminobutyric acid type A (GABA(A)) beta3 subunit gene is inactivated ('beta3 knockout mice') have been previously shown to have epilepsy, hypersensitive behavior, cleft palate, and a high incidence of neonatal mortality. In this study, we analyze whole-cell responses to GABA in neurons from beta3+/+, beta3+/- and beta3-/- mice. We demonstrate markedly decreased responses to GABA in both hippocampal and dorsal root ganglion neurons isolated from beta3-/- mice without major differences in the GABA concentration-response curves. We also utilize the subunit selective pharmacology of Zn2+ and the anticonvulsant drug loreclezole to help infer the presence of beta2 and gamma subunits in the GABA(A) receptors remaining in neurons from beta3-/- mice. |
